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Deteksi dan Identifikasi Senyawa Flavonoid Ekstrak Etanol Kulit Batang Tanaman Majapahit (Crescentia cujete) dengan LCMS

Fatimah Fatimah, Rahma Diyan Martha, Asmarani Kusumawati

Abstract


Tanaman Majapahit (Crescentia cujete) merupakan salah satu tanaman yang banyak tersebar di Indonesia. Namun, tanaman ini kurang mendapatkan perhatian, karena kurangnya informasi mengenai potensi tanaman tersebut. Flavonoid merupakan salah satu kelompok senyawa terbesar yang terdapat pada tanaman yang memiliki beberapa fungsi farmakologis dan medisinal, salah satunya anti kanker. Dalam penelitian ini, dilakukan deteksi dan identifikasi senyawa flavonoid pada ekstrak etanol kulit batang tanaman majapahit menggunakan LCMS, untuk mengetahui potensi tanaman majapahit sebagai salah satu kandidat tanaman potensial antikanker. Berdasarkan hasil deteksi menggunakan LCMS diketahui terdapat sekitar 88 senyawa yang terdeteksi, termasuk didalamnya 12 senyawa flavonoid. Senyawa flavonoid yang ditemukan, yaitu; acetoin, quercetine, kaempferol-3-O-rhamnoside, acacetin7-rutinoside, fortunellin, kaempferol 3-[6”-(3-hydroxy-3-methylglutaryl) glucoside], didymin, diosmin, hesperidin, rutin, narirutin 4’-glucoside, kaempferol 3-[6”-(3-hydroxy-3-methylglutaryl) glucoside]-7-glucoside. Kaempferol-3 -O-rhamnoside merupakan flavonoid dengan komposisi terbesar yakni, sebesar 4,072%. Keseluruhan flavonoid yang teridentifikasi memiliki potensi sebagai antikanker, kecuali acetoin dan fortunellin.


Keywords


antikanker; Crescentia cujete; ekstrak etanol; flavonoid; LCMS

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DOI: http://doi.org/10.25273/cheesa.v3i2.7688.88-98

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