SYNTHESIZE AND CHARACTERIZATION OF PVP/CA AND CHITOSAN NANOFIBER USING ELECTROSPINNING

MEURETTA ALAWIYAH PULUNGAN; RAFLI FANDU RAMADHANI; MEUTIA KAMILATUN NUHA AP IDJAN; IDA SRIYANTI; M RUDI SANJAYA; JAIDAN JAUHARI; RADIYATI UMI PARTAN

doi:10.25273/jpfk.v9i2.16916

SYNTHESIZE AND CHARACTERIZATION OF PVP/CA AND CHITOSAN NANOFIBER USING ELECTROSPINNING

MEURETTA ALAWIYAH PULUNGAN, RAFLI FANDU RAMADHANI, MEUTIA KAMILATUN NUHA AP IDJAN, IDA SRIYANTI, M RUDI SANJAYA, JAIDAN JAUHARI, RADIYATI UMI PARTAN

Abstract

Nanofibers is one of the results of composites that have an important role in the industrial field, wound dressing, drug delivery and tissue engineering. Manufacturing of nanofibers can be carried out using electrospinning. Electrospinning is an easy, fast and simple technique for produced fibers with sizes ranging from micrometers to nanometers. We explained how to produce and the characteristics of nanofibers. The purpose of this study was to see the characterization of PVP/CA fiber. The fiber were made with consentration of PVP 10.4% (w/w) and mixed with variation of chitosan 0.5%;1%;1.5% (w/w). Process parameter that used in this research such us flowrate 0,20 ml/hour, high voltage 12 kV, and speed of drum is 200 rpm with the distances to needle tip of collector is 75 cm. The result showed that the morphology of fiber PVP/CA are bead fiber and bead free. The average diameter of PVP/CA fibers was 234;267;325 nm. Adding chitosan made the diameter of fibers increase. The XRD result shown that the fibers of PVP/CA/AE has an amorf phase. The fibers were potentially used in any sectors.

Keywords

Electrospinning;Morphology;Nanotechnology;Polyvinylpirrolidone

References

Alim Bahmid, N., Syamsu, K., & Maddu, A. (2014). Pengaruh Ukuran Serat Selulosa Asetat Dan Penambahan Dietilen Glikol (Deg) Terhadap Sifat Fisik Dan Mekanik Bioplastik Influence of Cellulose Acetate Fibers Size and Diethylen Glikol (Deg) Addition on Physical and Mechanical Properties of Bioplastics. Jurnal Teknologi Industri Pertanian, 24(3), 226–234.

Almafie, M. R., Nawawi, Z., Jauhari, J., & Sriyanti, I. (2020). Electrospun of Poly (vinyl alcohol)/Potassium hydroxide (PVA/KOH) nanofiber composites using the electrospinning method. IOP Conference Series: Materials Science and Engineering, 850(1), 0–7. https://doi.org/10.1088/1757-899X/850/1/012051

Anisiei, A., Oancea, F., & Marin, L. (2023). Electrospinning of chitosan-based nanofibers: From design to prospective applications. Reviews in Chemical Engineering, 39(1), 31–70. https://doi.org/10.1515/revce-2021-0003

Bandatang, N., Pongsomboon, S., & Jumpapaeng, P. (2021). International Journal of Biological Macromolecules Antimicrobial electrospun nanofiber mats of NaOH-hydrolyzed chitosan ( HCS )/ PVP / PVA incorporated with in-situ synthesized AgNPs : Fabrication , characterization , and antibacterial activity. International Journal of Biological Macromolecules, 190(August), 585–600. https://doi.org/10.1016/j.ijbiomac.2021.08.209

Bayat, S., Amiri, N., Pishavar, E., Kalalinia, F., Movaffagh, J., & Hahsemi, M. (2019). Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models. Life Sciences, 229(May), 57–66. https://doi.org/10.1016/j.lfs.2019.05.028

Bonan, R. F., Bonan, P. R. F., Batista, A. U. D., Sampaio, F. C., Albuquerque, A. J. R., Moraes, M. C. B., Mattoso, L. H. C., Glenn, G. M., Medeiros, E. S., & Oliveira, J. E. (2015). In vitro antimicrobial activity of solution blow spun poly(lactic acid)/polyvinylpyrrolidone nanofibers loaded with Copaiba (Copaifera sp.) oil. Materials Science and Engineering C, 48, 372–377. https://doi.org/10.1016/j.msec.2014.12.021

Chen, C., Tang, Y., Vlahovic, B., & Yan, F. (2017). Electrospun Polymer Nanofibers Decorated with Noble Metal Nanoparticles for Chemical Sensing. Nanoscale Research Letters, 12. https://doi.org/10.1186/s11671-017-2216-4

Dai, X. Y., Nie, W., Wang, Y. C., Shen, Y., Li, Y., & Gan, S. J. (2012). Electrospun emodin polyvinylpyrrolidone blended nanofibrous membrane: A novel medicated biomaterial for drug delivery and accelerated wound healing. Journal of Materials Science: Materials in Medicine, 23(11), 2709–2716. https://doi.org/10.1007/s10856-012-4728-x

Elsayed, M. T., Hassan, A. A., Abdelaal, S. A., Taher, M. M., Ahmed, M. khalaf, & Shoueir, K. R. (2020). Morphological, antibacterial, and cell attachment of cellulose acetate nanofibers containing modified hydroxyapatite for wound healing utilizations. Journal of Materials Research and Technology, 9(6), 13927–13936. https://doi.org/10.1016/j.jmrt.2020.09.094

Erukhimovich, I., & de la Cruz, M. O. (2004). Phase equilibria and charge fractionation in polydisperse polyelectrolyte solutions. 1490–1498. https://doi.org/10.1002/polb

Grant, J. J., Pillai, S. C., Perova, T. S., Hehir, S., Hinder, S. J., McAfee, M., & Breen, A. (2021). Electrospun fibres of chitosan/PVP for the effective chemotherapeutic drug delivery of 5-fluorouracil. Chemosensors, 9(4), 1–19. https://doi.org/10.3390/chemosensors9040070

Gu, S. Y., Wang, Z. M., Ren, J., & Zhang, C. Y. (2009). Electrospinning of gelatin and gelatin/poly(l-lactide) blend and its characteristics for wound dressing. Materials Science and Engineering C, 29(6), 1822–1828. https://doi.org/10.1016/j.msec.2009.02.010

Huang, W., Wang, M. J., Liu, C. L., You, J., Chen, S. C., Wang, Y. Z., & Liu, Y. (2014). Phase separation in electrospun nanofibers controlled by crystallization induced self-assembly. Journal of Materials Chemistry A, 2(22), 8416–8424. https://doi.org/10.1039/c4ta00417e

Jauhari, J., Suharli, A. J., Saputra, R., Nawawi, Z., & Sriyanti, I. (2020). Polyvinylpyrollidone/Cellulose Acetate (PVA/CA) Fiber Size Prediction Using Scaling Law Model. Journal of Physics: Conference Series, 1467(1). https://doi.org/10.1088/1742-6596/1467/1/012049

Jauhari, J., Wiranata, S., Rahma, A., Nawawi, Z., & Sriyanti, I. (2019). Polyvinylpyrrolidone / Cellulose Acetate nanofibers synthesized using electrospinning method and their characteristics Polyvinylpyrrolidone / cellulose acetate nano fi bers synthesized using electrospinning method and their characteristics. Materials Research Express, 6(6), 64002. https://doi.org/10.1088/2053-1591/ab0b11

Jiang, S., Chen, Y., Duan, G., Mei, C., Greiner, A., & Agarwal, S. (2018). Electrospun nanofiber reinforced composites: A review. Polymer Chemistry, 9(20), 2685–2720. https://doi.org/10.1039/c8py00378e

Khoshnevisan, K., Maleki, H., Samadian, H., Shahsavari, S., Sarrafzadeh, M. H., Larijani, B., Dorkoosh, F. A., Haghpanah, V., & Khorramizadeh, M. R. (2018). Cellulose acetate electrospun nanofibers for drug delivery systems: Applications and recent advances. Carbohydrate Polymers, 198, 131–141. https://doi.org/10.1016/j.carbpol.2018.06.072

Konwarh, R., Karak, N., & Misra, M. (2013). Electrospun cellulose acetate nanofibers: The present status and gamut of biotechnological applications. Biotechnology Advances, 31(4), 421–437. https://doi.org/10.1016/j.biotechadv.2013.01.002

Kurakula, M., & Rao, G. S. N. K. (2020). Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition. Journal of Drug Delivery Science and Technology, 60(August), 102046. https://doi.org/10.1016/j.jddst.2020.102046

Li, X. Y., Wang, X., Yu, D. G., Ye, S., Kuang, Q. K., Yi, Q. W., & Yao, X. Z. (2012). Electrospun borneol-PVP nanocomposites. Journal of Nanomaterials, 2012. https://doi.org/10.1155/2012/731382

Marbelia, L., Bilad, M. R., & Vankelecom, I. F. J. (2019). Gradual PVP leaching from PVDF/PVP blend membranes and its effects on membrane fouling in membrane bioreactors. Separation and Purification Technology, 213(December 2018), 276–282. https://doi.org/10.1016/j.seppur.2018.12.045

Miao, J., Miyauchi, M., Simmons, T. J., Dordick, J. S., & Linhardt, R. J. (2010). Electrospinning of nanomaterials and applications in electronic components and devices. Journal of Nanoscience and Nanotechnology, 10(9), 5507–5519. https://doi.org/10.1166/jnn.2010.3073

Nada, A. A., El Aref, A. T., & Sharaf, S. S. (2019). The synthesis and characterization of zinc-containing electrospun chitosan/gelatin derivatives with antibacterial properties. International Journal of Biological Macromolecules, 133, 538–544. https://doi.org/10.1016/j.ijbiomac.2019.04.047

Nuryantini, A. Y., Ekaputra, M. P., Munir, M. M., & Suciati, T. (2014). Sintesis Nanoserat Poli(Vinil Alkohol) Dalam Bentuk Lembaran Dengan Pemintal Elektrik Multi Nozel Dan Kolektor Drum Synthesis of Poly(Vinyl Alcohol) Nanofibers Membrane Via Multi Nozzle Spinneret and Drum Collector. Jurnal Pendidikan Fisika Indonesia, 10(2), 186–193. https://doi.org/10.15294/jpfi.v10i2.3356

Paipitak, K., Pornpra, T., Mongkontalang, P., Techitdheer, W., & Pecharapa, W. (2011). Characterization of PVA-chitosan nanofibers prepared by electrospinning. Procedia Engineering, 8, 101–105. https://doi.org/10.1016/j.proeng.2011.03.019

Prayuddy, R., Edikresnha, D., & Miftahul, M. (2017). Encapsulation of β-carotene in poly(vinylpyrrolidone) (PVP) by electrospinning technique. Procedia Engineering, 170, 19–23. https://doi.org/10.1016/j.proeng.2017.03.004

Pusporini, P., Edikresnha, D., Sriyanti, I., Suciati, T., Munir, M. M., & Khairurrijal, K. (2018). Electrospun polyvinylpyrrolidone (PVP)/green tea extract composite nanofiber mats and their antioxidant activities. Materials Research Express, 5(5), 054001. https://doi.org/10.1088/2053-1591/aac1e6

Qin, J. J., Oo, M. H., & Li, Y. (2005). Development of high flux polyethersulfone hollow fiber ultrafiltration membranes from a low critical solution temperature dope via hypochlorite treatment. Journal of Membrane Science, 247(1–2), 137–142. https://doi.org/10.1016/j.memsci.2004.09.018

Qiu, H., Zhu, S., Pang, L., Ma, J., Liu, Y., Du, L., Wu, Y., & Jin, Y. (2020). ICG-loaded photodynamic chitosan/polyvinyl alcohol composite nanofibers: Anti-resistant bacterial effect and improved healing of infected wounds. International Journal of Pharmaceutics, 588(May), 119797. https://doi.org/10.1016/j.ijpharm.2020.119797

Ramakrishna, S., Fujihara, K., Teo, W., Lim, T., & Zuwei, M. (2005). An Introduction to Electrospinning and Nanofibers. World Scientific Publishing Co. Pte. Ltd.

Sriyanti, I., Edikresnha, D., Munir, M. M., & Rachmawati, H. (2017). Electrospun Polyvinylpyrrolidone ( PVP ) Nanofiber Mats Loaded by Garcinia mangostana L . Extracts. Material Science Forum, 880, 11–14. https://doi.org/10.4028/www.scientific.net/MSF.880.11

Sriyanti, I., Marlina, L., Fudholi, A., Marsela, S., & Jauhari, J. (2021). Physicochemical properties and in vitro evaluation studies of polyvinylpyrrolidone/cellulose acetate composite nanofibres loaded with Chromolaena odorata (L) King extract. Journal of Materials Research and Technology, 12, 333–342. https://doi.org/10.1016/j.jmrt.2021.02.083

Ullah, A., Saito, Y., Ullah, S., Haider, K., Nawaz, H., Duy-nam, P., Kharaghani, D., & Kim, I. S. (2020). Bioactive Sambong oil-loaded electrospun cellulose acetate nanofibers: Preparation, characterization, and in-vitro biocompatibility. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.257

Virginia, C., Khasanah, A., Jauhari, J., & Sriyanti, I. (2020). Electrospinning and characterization nanofibers and nano particle of Polyvinylpyrrolidone. IOP Conference Series: Materials Science and Engineering, 850(1). https://doi.org/10.1088/1757-899X/850/1/012039

Wang, J., & Zhuang, S. (2022). Chitosan-based materials: Preparation, modification and application. Journal of Cleaner Production, 355(March), 131825. https://doi.org/10.1016/j.jclepro.2022.131825

Wang, L., Yang, G., Wang, J., Wang, S., Wang, C., Peng, S., Yan, W., & Ramakrishna, S. (2019). In Situ Fabrication of Branched TiO2/C Nanofibers as Binder-Free and Free-Standing Anodes for High-Performance Sodium-Ion Batteries. Small, 15(30), 1901584. https://doi.org/https://doi.org/10.1002/smll.201901584

Xu, D., Samways, D. S. K., & Dong, H. (2017). Fabrication of self-assembling nanofibers with optimal cell uptake and therapeutic delivery efficacy. Bioactive Materials, 2(4), 260–268. https://doi.org/10.1016/j.bioactmat.2017.09.001

Xue, J., Wu, T., Dai, Y., Xia, Y., & States, U. (2018). Electrospinning and Electrospun Nano fi bers : Methods , Materials , and Applications [Review-article]. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.8b00593

Zhang, J., Chen, K., Ding, C., Sun, S., Zheng, Y., Ding, Q., Hong, B., & Liu, W. (2022). Fabrication of chitosan/PVP/dihydroquercetin nanocomposite film for in vitro and in vivo evaluation of wound healing. International Journal of Biological Macromolecules, 206(February), 591–604. https://doi.org/10.1016/j.ijbiomac.2022.02.110