Kajian Farmakoinformatika Senyawa Alkaloid Anggur Laut (Caulerpa racemose) Sebagai Inhibitor Collagenase Dalam Mekanisme Antiaging
Abstract
Caulerpa racemosa or sea grape is an edible macroalgae, cultivated and wild species in Asia ocean. Sea grapes also well known as functional food source from marine, contains high protein, fibers and secondari metabolites. The biological functions of sea grape also has been identified as antioxidant, antiinflammatory, antiobesity, and anticancer. However, the antiaging activity has not been known yet. This study investigated the potential antiaging activity of alkaloids compounds from sea grapes through inhibiting collagenase protein by farmacoinformatic study. six alkaloid structure of sea grapes including Caulerpin, Caulersin, Caulerchlorin, Racemosin A, Racemosin B, and Racemosin C, were retrieved from PubChem database and collagenase protein also was downloaded from Protein Data Bank with ID 2TCL. Six alkaloids of Caulerpa racemosa were redocked with collagenase at the specific site and were visualized by Discovery studio version 21.1.1. collagenase inhibitor compound also used as control for this study. farmacoinformatic analysis performed that six alkaloid of sea grapes and inhibitor compounds were showed at the same region of collagenase, which was identified as inhibitor sites. Several active residues of collagenase, involved SER139, PRO138, HIS128, and LEU81 were detected at six alkaloids compounds and control inhibitor, indicating six alkaloid of sea grapes potentially as collagenase inhibitor leading to antiaging properties. This study summarized that the six sea grape’s alkaloid has potential as collagenase inhibitor. Further in vivo analysis were required for further investigation.
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Andrade, Paula B. et al. 2013. “Valuable Compounds in Macroalgae Extracts.” Food Chemistry 138(2–3): 1819–28. http://dx.doi.org/10.1016/j.foodchem.2012.11.081.
Arunkumar, Malaisamy et al. 2021. “Marine Algal Antagonists Targeting 3CL Protease and Spike Glycoprotein of SARS-CoV-2: A Computational Approach for Anti-COVID-19 Drug Discovery.” Journal of Biomolecular Structure and Dynamics 0(0): 1–28. https://doi.org/10.1080/07391102.2021.1921032.
Bare, Yohanes; et al. 2022. “Kajian Senyawa Hexose Dan Malic Acid Sebagai Inhibitor Papain Like Protease ( PLPro ) Corona Virus.” Biosense 05(01): 128–37.
Bare, Yohanes, Andri Maulidi, Dewi Ratih Tirto Sari, and Sri Sulystyaningsih Natalia Daeng Tiring. 2019. “Studi in Silico Prediksi Potensi 6-Gingerol Sebagai Inhibitor c-Jun N-Terminal Kinases (JNK).” Jurnal Jejaring Matematika dan Sains 1(2): 59–63.
Bitencourt-Ferreira, Gabriela, and Walter Filgueira de Azevedo. 2019a. 2053 Methods in Molecular Biology Docking Screens for Drug Discovery. eds. Gabriela Bitencourt-Ferreira and Walter Filgueira de Azevedo. Ria Grande do Sul: Humana Press.
Bitencourt-Ferreira, Gabriela, and Walter Filgueira Jr de Azevedo. 2019b. “Molegro Virtual Docker for Docking.” Methods in molecular biology (Clifton, N.J.) 2053: 149–67.
Borkakoti, N et al. 1994. “Structure of the Catalytic Domain of Human Fibroblast Collagenase Complexed with an Inhibitor.” Nature Structural Biology 1(2): 106–10. https://doi.org/10.1038/nsb0294-106.
Choi, Hee Jeong et al. 2020. “Protection against UVB-Induced Photoaging by Nypa Fruticans via Inhibition of MAPK/AP-1/MMP-1 Signaling.” Oxidative Medicine and Cellular Longevity 2020: 1–14.
Duffy, J. Emmett. 2006. “Biodiversity and the Functioning of Seagrass Ecosystems.” Marine Ecology Progress Series 311(April 2006): 233–50.
Eun Lee, Kyung, Shiv Bharadwaj, Umesh Yadava, and Sang Gu Kang. 2019. “Evaluation of Caffeine as Inhibitor against Collagenase, Elastase and Tyrosinase Using in Silico and in Vitro Approach.” Journal of Enzyme Inhibition and Medicinal Chemistry 34(1): 927–36. https://doi.org/10.1080/14756366.2019.1596904.
Fait, Tomas. 2019. “Menopause Hormone Therapy: Latest Developments and Clinical Practice.” Drugs in Context 8: 1–9.
Fakhrulddin, I. M., Z. Muta Harah, R. D. Shiamala, and A. M. Azrie. 2021. “Effect of Salinity, Light and Fertilizer on Caulerpa Lentillifera under Culture Conditions.” In AIP Conference Proceedings, American Institute of Physics Inc.
Hakim, Masuma M., and Illa C. Patel. 2020. “A Review on Phytoconstituents of Marine Brown Algae.” Future Journal of Pharmaceutical Sciences 6(1).
Hartmann, Anja et al. 2015. “Inhibition of Collagenase by Mycosporine-like Amino Acids from Marine Sources.” Planta Medica 81(10): 813–20.
Krisnamurti, Gabriella Chandrakirana;, and Dewi Ratih Tirto; Sari. 2022. “Does Centella Asiatica Have Antiaging Activity in Skincare Products ?” Atlantis Press 630(Icetech 2021): 240–45.
Krisnamurti, Gabriella Chandrakirana;, Dewi Ratihtirto; Sari, and Yohanes Bare. 2021. “Capsaicinoids from Capsicum Annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis : In Silico Study Capsaicinoids from Capsicum Annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis : In Silico Study.” Makara Journal of Science 25(4): 195–202.
De La Garza, Ana Laura et al. 2011. “Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment.” Planta Medica 77(8): 773–85.
Leandro, Adriana et al. 2020. “Seaweed Phenolics: From Extraction to Applications.” Marine Drugs 18(8): 1–47.
Mechqoq, Hicham et al. 2022. “Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products.” Cosmetics 9(1).
Mohamed, Gamal A, Sabrin R M Ibrahim, Riham Salah, and El Dine. 2014. “Natural Anti-Obesity Agents.” Bulletin of Faculty of Pharmacy, Cairo University 52(2): 269–84. http://dx.doi.org/10.1016/j.bfopcu.2014.05.001.
Pradhan, Biswajita et al. 2020. “Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review.” Molecules (Basel, Switzerland) 26(1).
Rahmawati, S. I. et al. 2019. “Enzyme-Assisted Extraction of Fatty Acid from Caulerpa Lentilifera: A Preliminary Study.” In IOP Conference Series: Earth and Environmental Science, Institute of Physics Publishing.
Roy, Himadri Shekhar et al. 2022. “Molecular Docking and Molecular Dynamics to Identify Collagenase Inhibitors as Lead Compounds to Address Osteoarthritis.” Journal of biomolecular structure & dynamics 40(5): 2339–51.
Sari, Dewi Ratih Tirto; Krisnamurti, Gabriella Chandrakirana; 2021. “1-Dehydrogingerdione , Senyawa Volatil Jahe Sebagai Agen Sedatif Subtitutif γ - Aminobutyrate ( GABA ); Kajian Biokomputasi.” Prosiding Seminar Nasional Biologi 7(1): 389–95.
Sari, Dewi Ratih Tirto;, and Yohanes; Bare. 2021. “Kajian In Silico Aktivitas Antioksidan Senyawa Bioaktif Dalam Minyak Serai (Cymbopogon Citratus).” Al-Kimia 9(1): 61–69.
Sari, Dewi Ratih Tirto et al. 2021. “Kajian Bioinformatika Penghambatan Alosterik Asemanan Dan Glukomanan Terhadap C-JUN NH2 Terminal Kinase ( JNK ).” Spizaetus : Jurnal Biologi dan Pendidikan Biologi 2(2): 28–36.
Sari, Dewi Ratih Tirto, and Gabriella Chandrakirana Krisnamurti. 2022. “In Silico Repositioning Strategies of Theobromine and Caffeine for Psychiatric and Neurological Disorders.” Proceeding International Conference on Religion, Science and Education 1: 685–92.
Sari, Dewi Ratih Tirto, Anna Safitri, James R Ketudat; Cairns, and Fatchiyah Fatchiyah. 2020. “Anti-Apoptotic Activity of Anthocyanins Has Potential to Inhibit Caspase-3 Signaling.” Journal of Tropical Life Science 10(1): 15–25.
Shin, Jung Won et al. 2019. “Molecular Mechanisms of Dermal Aging and Antiaging Approaches.” International Journal of Molecular Sciences 20(9).
Sinurat, E., Nurhayati, D. Fransiska, and J. Basmal. 2021. “Characterization of the Physical Properties and Sensory Acceptability of Caulerpa Racemosa Grain Beverage.” In IOP Conference Series: Earth and Environmental Science, IOP Publishing Ltd.
Sinurat, Ellya, and Sofa Fadjriah. 2019. “The Chemical Properties of Seaweed Caulerpa Lentifera from Takalar, South Sulawesi.” In IOP Conference Series: Materials Science and Engineering, Institute of Physics Publishing.
Sugawara, Tatsuya et al. 2014. “Siphonaxanthin, a Green Algal Carotenoid, as a Novel Functional Compound.” Marine Drugs 12(6): 3660–68.
Tapotubun, Alfonsina Marthina et al. 2020. “Seaweed Caulerpa Sp Position as Functional Food.” In IOP Conference Series: Earth and Environmental Science, Institute of Physics Publishing.
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DOI: http://doi.org/10.25273/florea.v9i2.14434
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