Relationship between Amount of Drugs Taken and Warfarin Adherence
DOI:
https://doi.org/10.25273/pharmed.v3i2.7531Keywords:
number of drugs, warfarin, adherenceAbstract
Warfarin is a narrow therapeutic drug that needs to be monitored its use. Warfarin adherence is expected to improve warfarin control. However, the amount of drug taken can cause complications in its use which in turn can impact warfarin adherence. Therefore, this study aims to determine the relationship between the amount of medication taken with warfarin adherence. This study is an analytical observational study with a cross sectional design. The subjects of this study were adult patients (> 18 years old) at the cardiac clinic of PKU Muhammadiyah Yogyakarta Hospital who received warfarin and were willing to be a prescription. The number of research samples obtained was 35 patients. Measurement of adherence using a questionnaire Medication Adherence Rating Scale (MARS). Chi Square analysis was used to determine the relationship between the amount of medication taken and adherence to drinking warfarin. The results showed that there were 19 patients (54.3%) who took 4 drugs (54.3%) and 16 patients (45.7%) who took> 4 drugs. Patient adherence was divided into low and high adherence. A total of 18 patients (51.4%) had high adherence and 17 patients (48.6%) had low adherence. Based on the chi square analysis, there is a relationship between the number of drugs taken and adherence to taking warfarin (p = 0.04 <0.05).
Downloads
References
Ayele, A. A., Tegegn, H. G., Ayele, T. A., & Ayalew, M. B. (2019). Medication regimen complexity and its impact on medication adherence and glycemic control among patients with type 2 diabetes mellitus in an Ethiopian general hospital. BMJ Open Diabetes Research and Care, 7(1), 685. https://doi.org/10.1136/bmjdrc-2019-000685
Clark, N. P. (2018). Role of the anticoagulant monitoring service in 2018: Beyond warfarin. Hematology (United States), 2018(1), 348–352. https://doi.org/10.1182/asheducation-2018.1.348
Gallagher, C., Nyfort-Hansen, K., Rowett, D., Wong, C. X., Middeldorp, M. E., Mahajan, R., Lau, D. H., Sanders, P., & Hendriks, J. M. (2020). Polypharmacy and health outcomes in atrial fibrillation: a systematic review and meta-analysis. In Open Heart (Vol. 7, Issue 1). BMJ Publishing Group. https://doi.org/10.1136/openhrt-2020-001257
Kim, S. J., Kwon, O. D., Han, E. B., Lee, C. M., Oh, S.-W., Joh, H.-K., Oh, B., Kwon, H., Cho, B., & Choi, H. C. (2019). Impact of number of medications and age on adherence to antihypertensive medications. Medicine, 98(49), e17825. https://doi.org/10.1097/MD.0000000000017825
Kimmel, S. E., Chen, Z., Price, M., Parker, C. S., Metlay, J. P., Christie, J. D., Brensinger, C. M., Newcomb, C. W., Samaha, F. F., & Gross, R. (2007). The influence of patient adherence on anticoagulation control with warfarin: Results from the international normalized ratio adherence and genetics (IN-RANGE) study. Archives of Internal Medicine, 167(3), 229–235. https://doi.org/10.1001/archinte.167.3.229
Mariita, K., Nyamu, D. ., Maina, C. K., Karimi, P. ., Mugendi, G. A., & Menge, T. B. (2015). Patient Associated Factors that Affect Adherence to Warfarin Therapy in a Tertiary Referral Hospital in Kenya. East and Central African Journal of Pharmaceutical Sciences, 18(2), 43–50. https://www.researchgate.net/publication/314259729_Patient_Associated_Factors_that_Affect_Adherence_to_Warfarin_Therapy_in_a_Tertiary_Referral_Hospital_in_Kenya
Mayet, A. Y. (2016). Patient adherence to warfarin therapy and its impact on anticoagulation control. Saudi Pharmaceutical Journal, 24(1), 29–34. https://doi.org/10.1016/j.jsps.2015.02.005
Parker, C. S., Chen, Z., Price, M., Gross, R., Metlay, J. P., Christie, J. D., Brensinger, C. M., Newcomb, C. W., Samaha, F. F., & Kimmel, S. E. (2007). Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: Results from the IN-RANGE study. Journal of General Internal Medicine, 22(9), 1254–1259. https://doi.org/10.1007/s11606-007-0233-1
Patel, S., Singh, R., Preuss, C. V, & Patel, N. (2020). Warfarin. https://www.ncbi.nlm.nih.gov/books/NBK470313/
R., N., R., M. S., J., E. R., & M., K. S. (2019). Prescribing pattern and adverse drug reactions of cardiovascular drugs in out-patient department of a tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 8(4), 767. https://doi.org/10.18203/2319-2003.ijbcp20191114
Sabate, E. (2003). Adherence To Long-Term Therapies : Evidence For Action. WHO.
Tefera, Y. G., Alemayehu, M., & Mekonnen, G. B. (2020). Prevalence and determinants of polypharmacy in cardiovascular patients attending outpatient clinic in Ethiopia University Hospital. PLoS ONE, 15(6). https://doi.org/10.1371/journal.pone.0234000
Zelko, E., KlemencKetis, Z., & TusekBunc, K. (2016). Medication Adherence in Elderly with Polypharmacy Living at Home: a Systematic Review of Existing Studies. Materia Socio Medica, 28(2), 129. https://doi.org/10.5455/msm.2016.28.129-132
Downloads
Published
Issue
Section
License
With the receipt of the article by Pharmed Editorial Board and the decision to be published, the copyright regarding the article will be transferred to Pharmed Journal.
Pharmed has the right to multiply and distribute the article and every author is not allowed to publish the same article that was published in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
