Pola Penggunaan Antibiotik Pada Pasien Sepsis Rawat Inap Di RSUD Dr. MOEWARDI

Authors

  • Fera Nor Maliza RSIA Permata Bunda Ketapang
  • Alfiana Pramasita Gonibala Institut Kesehatan dan Teknologi Graha Medika

DOI:

https://doi.org/10.25273/pharmed.v6i1.15759

Keywords:

Antibiotik, Sepsis

Abstract

Sepsis merupakan respon sistemik terhadap infeksi yang dapat mempengaruhi hampir setiap sistem organ. Secara global kejadian sepsis mengalami peningkatan dengan angka kematian yang terus menerus semakin bertambah. Antibiotik merupakan salah satu komponen penting dalam penatalaksanaan kasus sepsis dan syok sepsis yang telah terbukti dapat menurunkan angka kematian dan harus diberikan segera setelah sepsis terdiagnosa. Penggunaan antibiotik yang efektif secara teoritis membantu mencegah perkembangan sepsis menjadi syok sepsis. Tujuan penelitian ini adalah untuk mengetahui pola penggunaan antibiotik pasien dengan diagnosa sepsis di RSUD Dr. Moewardi. Penelitian ini merupakan jenis penelitian observasional dengan menggunakan desain penelitian Cross sectional. Pengumpulan data dilakukan secara prospektif melalui penelusuran data rekam medis pasien sepsis yang sedang dirawat di bangsal rawat Inap RSUD Dr. Moewardi Hasil penelitian pada pasien sepsis Pola penggunaan antibiotik pada pasien sepsis di RSUD Dr. Moewardi terdapat 93 penggunaan antibiotik empiris dan 26 penggunaan antibiotik definitif. Mayoritas penggunaan antibiotik empiris yaitu ampisilin- sulbaktam (62.36%), kombinasi ampisilin/sulbaktam dan levofloxacin (20.43%) dan mayoritas penggunaan antibiotik definitif yaitu meropenem (21.73%), vancomycin (15.38%).

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Author Biography

Alfiana Pramasita Gonibala, Institut Kesehatan dan Teknologi Graha Medika

Farmasi

References

Cardozo Junior, L. C. M., & Silva, R. R. da. (2014). Sepsis in intensive care unit patients with traumatic brain injury: factors associated with higher mortality. Revista Brasileira de Terapia Intensiva, 26(2), 148–154. https://doi.org/10.5935/0103-507X.20140022

Clifford, K. M., Dy-boarman, E. A., Haase, K. K., Pass, S., & Alvarez, C. A. (2017). Challenges with Diagnosing and Managing Sepsis in Older Adults.HHSPublicAccess,14(2),231–241. https://doi.org/10.1586/14787210.2016.1135052.Challenges

Corsonello, A., Abbatecola, A. M., Fusco, S., Luciani, F., Marino, A., Catalano, S., … Lattanzio, F. (2015). The impact of drug interactions and polypharmacy on antimicrobial therapy in the elderly. Clinical Microbiology and Infection, 21(1), 20–26. https://doi.org/10.1016/j.cmi.2014.09.011

Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Moreno, R. (2013). Surviving Sepsis Campaign. Critical Care Medicine, 41(2), 580–637. https://doi.org/10.1097/CCM.0b013e31827e83af

Dewi, R. S., Radji, M., & Andalusia, R. (2018). Evaluation of Antibiotic Use Among Sepsis Patients in an Intensive Care Unit. Sultan Qaboos University Med J, 18(August), 367–373. https://doi.org/10.18295/squmj.2018.18.03.017

Ferrer, R., Martin-Loeches, I., Phillips, G., Osborn, T. M., Townsend, S., Dellinger, R. P., Levy, M. M. (2014). Empiric Antibiotic Treatment Reduces Mortality In Severe Sepsis And Septic Shock From The First Hour: Results From A Guideline-Based Performance Improvement Program. Critical Care Medicine, 42(8),1749–1755.https://doi.org/10.1097/CCM.0000000000000330

Garnacho-montero, J., Gutierrez-pizarraya, A., & Escoresca-ortega, A. (2015). Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality. Critical Care, 1–8. https://doi.org/10.1186/s13054-015-1000-z

Goncalves, J., & Povoa, P. (2011). Antibiotics In Critically Ill Patients: A Systematic Review Of The Pharmacokinetics Of Β-Lactams. Critical Care, 15(5), 1–17. https://doi.org/10.1186/cc10441.

Green, M. J., Peterson, S. K., Baker, M. W., Friedman, C., Harper, G. R., Rubinstein, W. S., Mauger, D. T. (2014). Septic Shock and Adequacy of Early Empiric Antibiotics in the Emergency Department. J Emerg Med,7(4), 221–229. https://doi.org/10.1016/j.molcel.2009.10.020.The

Guner, R., Hasanoglu, I., Keske, S., Kalem, A. K., & Tasyaran, M. A. (2011). Outcomes In Patients Infected With Carbapenem-Resistant Acinetobacter

Baumannii And Treated With Tigecycline Alone Or In Combination Therapy. Infection, 39(6), 515–518. https://doi.org/10.1007/s15010-011-

-1

Halbach, J. L., Wang, A. W., Hawisher, D., Cauvi, D. M., Lizardo, R. E., Rosas, J., De Maio, A. (2017). Why Antibiotic Treatment is Not Enough for sepsis Resolution: An Evaluation In An Experimental Animal Model. Infection and Immunity, 85(12), 1–11. https://doi.org/10.1128/IAI.00664-17

Hidayati, Arifin, H., & Raveinal. (2016). Kajian Penggunaan Antibiotik pada Pasien Sepsis dengan Gangguan Ginjal. Jurnal Sains Farmasi & Klinis, 2(2), 129–137.

Kolditz, M., & Ewig, S. (2017). Community-Acquired Pneumonia in Adults. Deutsches Arzteblatt International, 114(49), 838–848. https://doi.org/10.3238/arztebl.2017.0838

Lie, K. C., Lau, C., Chau, N. V. V., West, T. E., & Limmathurotsakul, D. (2018). Utility Of SOFA Score , Management And Outcomes Of Sepsis In Southeast Asia : A Multinational Multicenter Prospective Observational Study. 1–8.

Medam, S., Zieleskiewicz, L., Duclos, G., Baumstarck, K., Loundou, A., Alingrin, J., Leone, M. (2017). Risk Factors For Death In Septic Shock. Medicine Journal

Nachtigall, I., Tafelski, S., Rothbart, A., Kaufner, L., Schmidt, M., Tamarkin, A., Spies, C. (2011). Gender-Related Outcome Difference Is Related To Course Of Sepsis On Mixed Icus: A Prospective, Observational Clinical Study. Critical Care, 15(3). https://doi.org/10.1186/cc1027

Opal, S. M., Rubenfeld, G. D., Poll, T. Van Der, Vincent, J., & Angus, D. C. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). The Journal of the American Medical Association, 315(8), 801–810. https://doi.org/10.1001/jama.2016.0287

Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Dellinger, R. P. (2017). Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. In Critical Care Medicine (Vol. 45). https://doi.org/10.1097/CCM.0000000000002255

Ronald Pratama, Sustini, F., Hardiono, Widodo, A. D. W., Hidajat, B., & Hadi, U. (2018). Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method. Oceana Biomedicina Journal Vol 1 No 2. 1(2), 69–78.

Tamma, P. D., Cosgrove, S. E., & Maragakis, L. L. (2012). Combination Therapy for Treatment of Infections with Gram-Negative Bacteria. ASM.Org, 25(3), 450–470. https://doi.org/10.1128/CMR.05041-11

Zamoner, W., Souza, D. S. De, Oliveira, M. G. De, & Ponce, D. (2016). The Use Of Antimicrobials In Septic Patients With Acute Kidney Injury. 39(3):323-, 323–328. https://doi.org/10.5935/0101-2800.20170055

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Published

2023-05-24

Issue

Vol. 6 No. 1 (2023)

Section

Articles

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