Comparative Effect of Honey Bee Venom and Common Antifungal Agents on Candida albicans
DOI:
https://doi.org/10.25273/pharmed.v5i2.13468Keywords:
Candida albicans, bee venom (BV), antifungal, pharmacology, infectionsAbstract
Fungal infections, can cause various symptoms in different forms, and are associated with high morbidity and mortality in vulnerable groups. one of the most significant fungal infection is candidiasis which caused by Candida. In recent years, there has been growing worried about the challenging of fungal diseases treatment and unwanted consequence of synthetic antifungal drugs. This necessitates the searching for new classes of broad-spectrum anti-fungal drugs to bring pharmaceutical characteristics and more efficient treatments. Bee venom (BV) is an antimicrobial agent which has been widely used to treat various diseases. the aim of the current study was to examine the antifungal properties of honey bee venom on Candida albicans to compare it to some common antifungal drugs (ketoconazole and amphotericin B). to perform this assay, the standard strains of C. albicans (ATCC10231) was used for antimicrobial assessment, and Disc diffusion assay and the microbroth dilution method were used to evaluate the anti fungal activity of (BV). The result of this study showed that BV, amphotericin B and ketoconazole had inhibitory effects on C. albicans which MIC of the were measured to be 118.2, 3.3 and 2 respectively, furthermore, Comparison of BV and common antifungal drugs demonstrated that, amphotricin B and ketoconazole have a better effect on C. albicans.
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