Retno Aliyatul Fikroh


Synthesis of chalcone derivated has been synthhesized, structurally determined, and the in vitro cytotoxic activityof T47D cell was evaluated. A novel 2-bromo-4,5-dimethoxychalcone was synthesized by Claisen-Schmidt condensation of acetophenone with 6-bromoveratraldehyde. The synthesis of chalcone was carried out by reflux condition (65°C) for 24 hours using ethanol as a solvent and NaOH as a catalyst. The results showed that these coumpoun produced 81% in yield. The purity of synthesized product was determined by Thin Layer Chromatography. Structure identification was performed by FT-IR and 1H dan 13C-NMR spectrometer. In vitro activity test indicated that 2-bromo-4,5-dimethoxychalcone was not active for inhibiting the growth of T47D with IC50 value more than 100 µg/mL.


chalcone; synthesis; T47D cancer cell

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